During 1872 to 1880, Dr. Mackay had been preaching to the Taiwanese people outdoors until he felt the need to build a school. Therefore, when he returned to Britain in 1880, he raised money for the school. Construction of Oxford College completed in 1882. In honor of the British contributors, he named the school after his hometown, Oxford. Oxford College has the characteristics of traditional Chinese architecture with a symmetrical structure. There are 8 little Buddhist towers on the roof instead of crucifixes. The school engaged in training missionaries, medial workers and teachers. The building has been listed as second grade historical site.